Predicted to enable growth factor binding activity and serine-type endopeptidase activity. Involved in several processes, including negative regulation of protein secretion; regulation of epidermal growth factor receptor signaling pathway; and regulation of proteasomal protein catabolic process. Located in Golgi membrane and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RHBDF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHBDF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHBDF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:52,954–54,208 | 18.9 kb | Distal (>10kb) Multiome | 950 | |
| chr16:65,764–65,963 | 6.7 kb | Proximal (<10kb) | 455 | |
| chr16:71,378–73,062 | 1.1 kb | Proximal (<10kb) Multiome | 639 | |
| chr16:74,066–76,353 | 1.4 kb | Proximal (<10kb) | 441 | |
| chr16:77,240–78,636 | 5.5 kb | Proximal (<10kb) Multiome | 685 | |
| chr16:138,551–139,186 | 66.0 kb | Distal (>10kb) Multiome | 674 | |
| chr16:164,983–166,147 | 92.5 kb | Distal (>10kb) Multiome | 234 | |
| chr16:180,313–181,713 | 108.9 kb | Distal (>10kb) Multiome | 994 | |
| chr16:228,869–229,598 | 156.7 kb | Distal (>10kb) Multiome | 1035 | |
| chr16:234,152–235,669 | 162.2 kb | Distal (>10kb) Multiome | 908 | |
| chr16:351,804–354,436 | 280.3 kb | Distal (>10kb) Multiome | 654 | |
| chr16:378,999–379,813 | 306.7 kb | Distal (>10kb) Multiome HiCAR | 225 |
Genomic view of the RHBDF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.