The protein encoded by this gene is a member of the rhomboid family of membrane-bound proteases and is overexpressed in some breast cancers. Members of this family are involved in intramembrane proteolysis. In mouse, the orthologous protein associates with the Golgi body. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for RHBDD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHBDD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHBDD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:75,638,467–75,640,092 | 239.4 kb | Distal (>10kb) Multiome | 654 | |
| chr7:75,738,406–75,739,915 | 139.8 kb | Distal (>10kb) Multiome | 795 | |
| chr7:75,778,655–75,779,512 | 99.9 kb | Distal (>10kb) Multiome | 54 | |
| chr7:75,780,667–75,781,151 | 98.2 kb | Distal (>10kb) Multiome | 106 | |
| chr7:75,788,149–75,788,821 | 90.6 kb | Distal (>10kb) Multiome | 95 | |
| chr7:75,878,577–75,879,573 | 39 bp | At TSS Multiome | 883 | |
| chr7:75,881,608–75,881,832 | 2.6 kb | Proximal (<10kb) | 50 | |
| chr7:75,914,282–75,915,911 | 36.0 kb | Distal (>10kb) Multiome | 1021 | |
| chr7:75,993,473–75,995,401 | 115.6 kb | Distal (>10kb) Multiome | 873 | |
| chr7:76,047,582–76,048,952 | 169.0 kb | Distal (>10kb) Multiome | 920 | |
| chr7:76,073,173–76,073,663 | 194.5 kb | Distal (>10kb) Multiome | 100 | |
| chr7:76,163,449–76,164,544 | 284.9 kb | Distal (>10kb) Multiome | 132 | |
| chr7:76,166,338–76,167,166 | 287.7 kb | Distal (>10kb) Multiome | 644 | |
| chr7:76,177,965–76,178,641 | 299.3 kb | Distal (>10kb) Multiome | 670 |
Genomic view of the RHBDD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.