This gene encodes a protein that binds to all members of the R7 subfamily of regulators of G protein signaling and regulates their translocation between the nucleus and the plasma membrane. The encoded protein could be regulated by reversible palmitoylation, which anchors it to the plasma membrane. Depalmitoylation localizes the protein to the nucleus. Polymorphisms in this gene may be associated with risk of aspirin-exacerbated respiratory disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for RGS7BP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RGS7BP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RGS7BP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:64,497,477–64,497,708 | 8.5 kb | Proximal (<10kb) | 116 | |
| chr5:64,502,228–64,502,797 | 3.5 kb | Proximal (<10kb) | 47 | |
| chr5:64,505,514–64,507,841 | 354 bp | At TSS Multiome | 447 | |
| chr5:64,513,456–64,513,704 | 7.2 kb | Proximal (<10kb) | 12 | |
| chr5:64,690,060–64,691,616 | 184.5 kb | Distal (>10kb) Multiome | 408 | |
| chr5:64,705,728–64,706,826 | 200.0 kb | Distal (>10kb) Multiome | 254 | |
| chr5:64,767,999–64,769,372 | 262.4 kb | Distal (>10kb) Multiome | 909 | |
| chr5:65,562,647–65,563,667 | 1057.0 kb | Distal (>10kb) Multiome HiCAR | 818 |
Genomic view of the RGS7BP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.