This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for RGS6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RGS6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RGS6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:71,129,419–71,131,060 | 802.4 kb | Distal (>10kb) Multiome HiCAR | 219 | |
| chr14:71,675,065–71,675,809 | 257.0 kb | Distal (>10kb) Multiome | 150 | |
| chr14:71,764,455–71,765,204 | 167.6 kb | Distal (>10kb) Multiome | 75 | |
| chr14:71,776,411–71,777,708 | 155.5 kb | Distal (>10kb) Multiome | 230 | |
| chr14:71,931,936–71,933,304 | 60 bp | At TSS Multiome | 394 | |
| chr14:71,933,408–71,933,582 | 980 bp | At TSS | 59 |
Genomic view of the RGS6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.