This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for RGS3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RGS3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RGS3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:113,220,980–113,222,241 | 279.9 kb | Distal (>10kb) Multiome | 819 | |
| chr9:113,274,845–113,275,974 | 225.8 kb | Distal (>10kb) Multiome HiCAR | 852 | |
| chr9:113,339,770–113,340,691 | 161.1 kb | Distal (>10kb) Multiome | 941 | |
| chr9:113,349,409–113,349,994 | 151.7 kb | Distal (>10kb) Multiome | 358 | |
| chr9:113,376,590–113,377,575 | 124.3 kb | Distal (>10kb) Multiome | 710 | |
| chr9:113,400,912–113,402,007 | 100.0 kb | Distal (>10kb) Multiome | 859 | |
| chr9:113,409,973–113,410,921 | 90.8 kb | Distal (>10kb) Multiome HiCAR | 997 | |
| chr9:113,455,342–113,455,605 | 8.1 kb | Proximal (<10kb) | 296 | |
| chr9:113,463,361–113,464,008 | 37.7 kb | Distal (>10kb) Multiome HiCAR | 526 | |
| chr9:113,541,084–113,541,543 | 40.0 kb | Distal (>10kb) Multiome HiCAR | 160 | |
| chr9:113,564,824–113,565,252 | at TSS | At TSS | 237 | |
| chr9:113,591,435–113,592,161 | 90.4 kb | Distal (>10kb) Multiome HiCAR | 345 | |
| chr9:113,593,578–113,594,410 | 92.6 kb | Distal (>10kb) Multiome HiCAR | 433 | |
| chr9:113,602,171–113,602,614 | 8.0 kb | Proximal (<10kb) | 374 |
Genomic view of the RGS3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.