RGS16

regulator of G protein signaling 16 | A28-RGS14, RGS-r

The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]

Developmental clusters: GC3

Biological processes 20 terms

G protein-coupled receptor signaling pathway (GO:0007186)G protein-coupled receptor signaling pathway (GO:0007186)G protein-coupled receptor signaling pathway (GO:0007186)GTPase activator activity (GO:0005096)GTPase activator activity (GO:0005096)GTPase activator activity (GO:0005096)GTPase activator activity (GO:0005096)GTPase activity (GO:0003924)GTPase activity (GO:0003924)calmodulin binding (GO:0005516)cytoplasm (GO:0005737)cytoplasmic side of plasma membrane (GO:0009898)membrane (GO:0016020)membrane (GO:0016020)negative regulation of G protein-coupled receptor signaling pathway (GO:0045744)plasma membrane (GO:0005886)positive regulation of GTPase activity (GO:0043547)protein binding (GO:0005515)regulation of G protein-coupled receptor signaling pathway (GO:0008277)visual perception (GO:0007601)

Expression (TPM)

TFs regulating RGS16 0 TFs

Transcription factors with Perturb-seq knockdown data for RGS16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RGS16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RGS16

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RGS16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:181,101,491–181,102,447	1502.5 kb	Distal (>10kb) Multiome HiCAR	425
chr1:181,104,541–181,106,069	1499.0 kb	Distal (>10kb) Multiome HiCAR	849
chr1:182,084,244–182,085,384	519.3 kb	Distal (>10kb) Multiome HiCAR	393
chr1:182,309,693–182,310,287	294.5 kb	Distal (>10kb) Multiome	338
chr1:182,314,613–182,315,651	289.3 kb	Distal (>10kb) Multiome	258
chr1:182,390,343–182,392,611	212.5 kb	Distal (>10kb) Multiome	1089
chr1:182,595,753–182,595,977	8.4 kb	Proximal (<10kb)	176
chr1:182,597,753–182,598,046	6.3 kb	Proximal (<10kb)	9
chr1:182,599,447–182,599,662	4.7 kb	Proximal (<10kb)	72
chr1:182,601,428–182,602,027	2.4 kb	Proximal (<10kb)	304
chr1:182,603,748–182,604,847	29 bp	At TSS Multiome	617
chr1:182,611,551–182,612,259	7.6 kb	Proximal (<10kb) Multiome	222
chr1:182,613,228–182,613,696	8.8 kb	Proximal (<10kb)	7
chr1:182,614,397–182,617,189	10.6 kb	Distal (>10kb) Multiome	882
chr1:182,699,357–182,700,582	95.7 kb	Distal (>10kb) Multiome	237
chr1:182,789,198–182,790,098	185.3 kb	Distal (>10kb) Multiome HiCAR	771
chr1:182,806,097–182,806,606	202.0 kb	Distal (>10kb) Multiome HiCAR	157
chr1:182,838,565–182,840,149	235.0 kb	Distal (>10kb) Multiome HiCAR	1015

Genome Browser

Genomic view of the RGS16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.