Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RGS10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RGS10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RGS10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:119,542,175–119,543,695 | 123 bp | At TSS Multiome | 709 | |
| chr10:119,596,043–119,597,595 | 54.3 kb | Distal (>10kb) Multiome | 893 | |
| chr10:119,650,691–119,652,293 | 108.6 kb | Distal (>10kb) Multiome | 828 | |
| chr10:119,660,009–119,660,666 | 117.7 kb | Distal (>10kb) Multiome | 146 | |
| chr10:119,686,526–119,688,685 | 145.5 kb | Distal (>10kb) Multiome | 790 | |
| chr10:119,725,081–119,726,842 | 183.3 kb | Distal (>10kb) Multiome | 818 | |
| chr10:119,817,887–119,819,190 | 275.8 kb | Distal (>10kb) Multiome | 334 |
Genomic view of the RGS10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.