Predicted to enable all-trans-retinol 13,14-reductase activity. Predicted to be involved in retinol metabolic process. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RETSAT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RETSAT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RETSAT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:85,066,689–85,067,387 | 287.5 kb | Distal (>10kb) Multiome | 352 | |
| chr2:85,119,847–85,120,292 | 234.5 kb | Distal (>10kb) Multiome | 127 | |
| chr2:85,132,493–85,135,747 | 221.3 kb | Distal (>10kb) Multiome | 660 | |
| chr2:85,174,805–85,176,312 | 178.9 kb | Distal (>10kb) Multiome | 399 | |
| chr2:85,178,933–85,179,785 | 175.3 kb | Distal (>10kb) Multiome | 95 | |
| chr2:85,237,653–85,238,609 | 116.4 kb | Distal (>10kb) Multiome | 190 | |
| chr2:85,255,366–85,256,615 | 98.4 kb | Distal (>10kb) Multiome | 414 | |
| chr2:85,285,331–85,285,778 | 68.9 kb | Distal (>10kb) Multiome | 463 | |
| chr2:85,327,503–85,328,538 | 26.5 kb | Distal (>10kb) Multiome | 1009 | |
| chr2:85,354,014–85,355,224 | 103 bp | At TSS Multiome | 962 | |
| chr2:85,356,248–85,356,532 | 1.7 kb | Proximal (<10kb) | 15 | |
| chr2:85,413,587–85,414,333 | 59.3 kb | Distal (>10kb) Multiome | 351 | |
| chr2:85,418,133–85,419,210 | 64.1 kb | Distal (>10kb) Multiome | 885 | |
| chr2:85,420,473–85,421,406 | 66.3 kb | Distal (>10kb) Multiome | 853 | |
| chr2:85,437,445–85,438,463 | 83.3 kb | Distal (>10kb) Multiome | 501 | |
| chr2:85,455,501–85,456,436 | 101.4 kb | Distal (>10kb) Multiome | 268 | |
| chr2:85,468,626–85,469,195 | 114.3 kb | Distal (>10kb) Multiome | 496 | |
| chr2:85,537,623–85,540,152 | 183.2 kb | Distal (>10kb) Multiome | 1210 | |
| chr2:85,546,252–85,547,149 | 192.0 kb | Distal (>10kb) Multiome | 418 | |
| chr2:85,561,042–85,561,982 | 207.0 kb | Distal (>10kb) Multiome | 903 | |
| chr2:85,577,411–85,578,045 | 223.0 kb | Distal (>10kb) Multiome HiCAR | 505 | |
| chr2:85,578,935–85,580,041 | 225.1 kb | Distal (>10kb) Multiome HiCAR | 275 | |
| chr2:85,584,249–85,584,853 | 230.0 kb | Distal (>10kb) Multiome | 633 | |
| chr2:85,595,068–85,596,226 | 241.1 kb | Distal (>10kb) Multiome | 804 | |
| chr2:85,601,954–85,603,493 | 248.2 kb | Distal (>10kb) Multiome | 852 | |
| chr2:85,611,558–85,612,589 | 257.5 kb | Distal (>10kb) Multiome | 875 | |
| chr2:85,615,831–85,616,609 | 261.6 kb | Distal (>10kb) Multiome | 898 |
Genomic view of the RETSAT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.