Predicted to enable endoplasmic reticulum-autophagosome adaptor activity. Predicted to be involved in autophagy. Predicted to act upstream of or within collagen catabolic process; endoplasmic reticulum organization; and reticulophagy. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for RETREG2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RETREG2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RETREG2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:218,883,560–218,884,239 | 294.4 kb | Distal (>10kb) Multiome | 190 | |
| chr2:218,892,714–218,893,400 | 285.3 kb | Distal (>10kb) Multiome | 591 | |
| chr2:218,898,077–218,898,730 | 279.9 kb | Distal (>10kb) Multiome | 624 | |
| chr2:218,908,757–218,909,543 | 269.1 kb | Distal (>10kb) Multiome | 885 | |
| chr2:218,959,145–218,960,352 | 218.7 kb | Distal (>10kb) Multiome | 416 | |
| chr2:218,962,902–218,964,278 | 215.0 kb | Distal (>10kb) Multiome | 768 | |
| chr2:218,979,814–218,980,492 | 198.1 kb | Distal (>10kb) Multiome | 499 | |
| chr2:218,984,382–218,985,013 | 193.6 kb | Distal (>10kb) Multiome | 126 | |
| chr2:218,992,930–218,994,312 | 184.7 kb | Distal (>10kb) Multiome | 265 | |
| chr2:218,995,885–218,998,018 | 182.0 kb | Distal (>10kb) Multiome | 534 | |
| chr2:218,998,611–219,003,562 | 176.2 kb | Distal (>10kb) Multiome | 941 | |
| chr2:219,057,853–219,058,462 | 120.1 kb | Distal (>10kb) Multiome HiCAR | 469 | |
| chr2:219,060,260–219,061,256 | 117.4 kb | Distal (>10kb) Multiome | 240 | |
| chr2:219,159,910–219,161,297 | 17.7 kb | Distal (>10kb) Multiome | 901 | |
| chr2:219,176,168–219,177,450 | 1.4 kb | Proximal (<10kb) Multiome | 999 | |
| chr2:219,177,596–219,178,930 | 27 bp | At TSS Multiome | 930 | |
| chr2:219,206,194–219,207,456 | 28.6 kb | Distal (>10kb) Multiome | 861 | |
| chr2:219,217,908–219,219,751 | 40.7 kb | Distal (>10kb) Multiome HiCAR | 1058 | |
| chr2:219,228,940–219,230,470 | 51.4 kb | Distal (>10kb) Multiome | 914 | |
| chr2:219,245,074–219,245,804 | 67.2 kb | Distal (>10kb) Multiome | 891 | |
| chr2:219,252,908–219,254,656 | 75.7 kb | Distal (>10kb) Multiome | 808 | |
| chr2:219,277,516–219,280,537 | 101.1 kb | Distal (>10kb) Multiome | 1073 | |
| chr2:219,294,524–219,295,391 | 116.7 kb | Distal (>10kb) Multiome HiCAR | 892 | |
| chr2:219,308,224–219,309,089 | 130.1 kb | Distal (>10kb) Multiome HiCAR | 742 | |
| chr2:219,386,994–219,389,117 | 210.0 kb | Distal (>10kb) Multiome | 911 | |
| chr2:219,402,761–219,403,203 | 224.7 kb | Distal (>10kb) Multiome | 234 | |
| chr2:219,418,154–219,419,089 | 240.4 kb | Distal (>10kb) Multiome | 147 | |
| chr2:219,433,920–219,435,459 | 255.9 kb | Distal (>10kb) Multiome | 315 | |
| chr2:219,441,439–219,442,557 | 263.7 kb | Distal (>10kb) Multiome | 338 | |
| chr2:219,447,946–219,449,531 | 270.6 kb | Distal (>10kb) Multiome | 244 | |
| chr2:219,476,330–219,477,528 | 298.5 kb | Distal (>10kb) Multiome | 373 |
Genomic view of the RETREG2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.