This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis. [provided by RefSeq, Sep 2017]
Transcription factors with Perturb-seq knockdown data for RET. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RET upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RET, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:42,782,066–42,783,465 | 294.3 kb | Distal (>10kb) Multiome | 1124 | |
| chr10:42,866,108–42,867,222 | 210.2 kb | Distal (>10kb) Multiome HiCAR | 204 | |
| chr10:42,932,398–42,934,239 | 144.1 kb | Distal (>10kb) Multiome | 252 | |
| chr10:42,951,596–42,953,009 | 124.7 kb | Distal (>10kb) Multiome HiCAR | 263 | |
| chr10:43,026,131–43,027,199 | 50.3 kb | Distal (>10kb) Multiome | 308 | |
| chr10:43,076,256–43,078,068 | 37 bp | At TSS Multiome | 337 | |
| chr10:43,078,817–43,079,205 | 1.8 kb | Proximal (<10kb) | 117 | |
| chr10:43,104,555–43,106,082 | 28.5 kb | Distal (>10kb) Multiome | 582 | |
| chr10:43,137,532–43,139,055 | 61.4 kb | Distal (>10kb) Multiome | 754 | |
| chr10:43,202,016–43,204,485 | 125.8 kb | Distal (>10kb) Multiome | 505 | |
| chr10:43,204,643–43,205,459 | 128.1 kb | Distal (>10kb) Multiome | 272 | |
| chr10:43,228,465–43,230,305 | 152.7 kb | Distal (>10kb) Multiome | 290 | |
| chr10:43,265,915–43,267,309 | 189.8 kb | Distal (>10kb) Multiome | 244 | |
| chr10:43,322,425–43,323,518 | 245.9 kb | Distal (>10kb) Multiome | 215 | |
| chr10:43,361,820–43,362,935 | 285.3 kb | Distal (>10kb) Multiome | 416 | |
| chr10:43,395,694–43,397,607 | 319.1 kb | Distal (>10kb) Multiome | 1120 |
Genomic view of the RET locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.