RECQL4

RecQ like helicase 4 | RecQ4

The protein encoded by this gene is a DNA helicase that belongs to the RecQ helicase family. DNA helicases unwind double-stranded DNA into single-stranded DNAs and may modulate chromosome segregation. This gene is predominantly expressed in thymus and testis. Mutations in this gene are associated with Rothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [provided by RefSeq, Jan 2010]

Biological processes 32 terms

3'-5' DNA helicase activity (GO:0043138)ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)DNA recombination (GO:0006310)DNA repair (GO:0006281)DNA repair (GO:0006281)DNA replication (GO:0006260)DNA replication (GO:0006260)DNA replication (GO:0006260)DNA/DNA annealing activity (GO:1990814)bubble DNA binding (GO:0000405)catalytic activity, acting on DNA (GO:0140097)chromosome (GO:0005694)chromosome, telomeric region (GO:0000781)cytoplasm (GO:0005737)cytoplasm (GO:0005737)double-strand break repair via homologous recombination (GO:0000724)four-way junction helicase activity (GO:0009378)helicase activity (GO:0004386)helicase activity (GO:0004386)membrane (GO:0016020)nucleic acid binding (GO:0003676)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)oxidized purine DNA binding (GO:0032357)protein binding (GO:0005515)telomere maintenance (GO:0000723)telomere maintenance (GO:0000723)telomeric D-loop binding (GO:0061821)telomeric D-loop disassembly (GO:0061820)telomeric D-loop disassembly (GO:0061820)

Expression (TPM)

TFs regulating RECQL4 0 TFs

Transcription factors with Perturb-seq knockdown data for RECQL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RECQL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RECQL4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RECQL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:144,266,293–144,267,098	251.3 kb	Distal (>10kb) Multiome	162
chr8:144,290,981–144,292,410	226.3 kb	Distal (>10kb) Multiome	716
chr8:144,315,833–144,316,450	201.7 kb	Distal (>10kb) Multiome	396
chr8:144,325,768–144,327,719	190.9 kb	Distal (>10kb) Multiome	1016
chr8:144,331,281–144,333,847	185.8 kb	Distal (>10kb) Multiome	406
chr8:144,336,102–144,339,119	180.9 kb	Distal (>10kb) Multiome	922
chr8:144,353,907–144,355,227	163.3 kb	Distal (>10kb) Multiome	280
chr8:144,358,142–144,359,070	159.3 kb	Distal (>10kb) Multiome	719
chr8:144,369,349–144,369,916	148.1 kb	Distal (>10kb) Multiome	204
chr8:144,372,497–144,372,883	145.1 kb	Distal (>10kb) Multiome	160
chr8:144,372,993–144,375,084	143.9 kb	Distal (>10kb) Multiome	903
chr8:144,408,968–144,410,189	108.4 kb	Distal (>10kb) Multiome	920
chr8:144,427,691–144,429,571	89.2 kb	Distal (>10kb) Multiome	1000
chr8:144,443,691–144,445,047	73.5 kb	Distal (>10kb) Multiome	743
chr8:144,462,568–144,463,422	54.9 kb	Distal (>10kb) Multiome HiCAR	548
chr8:144,463,885–144,468,178	52.1 kb	Distal (>10kb) Multiome HiCAR	910
chr8:144,471,960–144,474,391	45.3 kb	Distal (>10kb) Multiome HiCAR	482
chr8:144,474,517–144,476,543	42.0 kb	Distal (>10kb) Multiome HiCAR	321
chr8:144,477,277–144,478,749	39.8 kb	Distal (>10kb) Multiome HiCAR	679
chr8:144,478,851–144,479,509	38.5 kb	Distal (>10kb) Multiome HiCAR	392
chr8:144,483,979–144,484,843	33.5 kb	Distal (>10kb) Multiome	125
chr8:144,495,748–144,496,431	21.7 kb	Distal (>10kb) Multiome	131
chr8:144,500,182–144,501,505	16.8 kb	Distal (>10kb) Multiome	484
chr8:144,507,995–144,510,268	9.0 kb	Proximal (<10kb) Multiome	1067
chr8:144,512,021–144,512,229	5.6 kb	Proximal (<10kb)	89
chr8:144,517,168–144,518,442	71 bp	At TSS Multiome	637
chr8:144,521,935–144,523,450	4.7 kb	Proximal (<10kb) Multiome	663
chr8:144,524,105–144,525,099	6.8 kb	Proximal (<10kb) Multiome	264
chr8:144,526,399–144,529,305	9.2 kb	Proximal (<10kb) Multiome	934
chr8:144,529,455–144,530,630	12.3 kb	Distal (>10kb) Multiome	284
chr8:144,580,290–144,581,657	62.9 kb	Distal (>10kb) Multiome	271
chr8:144,672,507–144,672,989	155.0 kb	Distal (>10kb) Multiome	150
chr8:144,684,108–144,686,340	166.6 kb	Distal (>10kb) Multiome	862
chr8:144,755,078–144,755,956	237.8 kb	Distal (>10kb) Multiome	769
chr8:144,785,987–144,788,592	269.3 kb	Distal (>10kb) Multiome	997
chr8:144,791,751–144,793,221	274.6 kb	Distal (>10kb) Multiome HiCAR	899
chr8:144,798,389–144,799,501	281.1 kb	Distal (>10kb) Multiome HiCAR	832

Genome Browser

Genomic view of the RECQL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.