This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for REC8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = REC8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of REC8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:23,910,478–23,911,853 | 261.2 kb | Distal (>10kb) Multiome | 310 | |
| chr14:23,953,479–23,954,293 | 218.2 kb | Distal (>10kb) Multiome | 897 | |
| chr14:23,988,469–23,989,172 | 183.2 kb | Distal (>10kb) Multiome | 439 | |
| chr14:24,036,218–24,036,993 | 135.5 kb | Distal (>10kb) Multiome | 627 | |
| chr14:24,051,239–24,052,875 | 120.1 kb | Distal (>10kb) Multiome | 821 | |
| chr14:24,080,914–24,082,038 | 90.5 kb | Distal (>10kb) Multiome | 706 | |
| chr14:24,093,491–24,095,115 | 77.8 kb | Distal (>10kb) Multiome | 990 | |
| chr14:24,113,681–24,115,917 | 57.1 kb | Distal (>10kb) Multiome | 1166 | |
| chr14:24,135,549–24,136,884 | 35.9 kb | Distal (>10kb) Multiome | 778 | |
| chr14:24,140,526–24,142,331 | 30.3 kb | Distal (>10kb) Multiome | 1034 | |
| chr14:24,146,204–24,148,108 | 25.2 kb | Distal (>10kb) Multiome | 918 | |
| chr14:24,160,877–24,161,762 | 10.8 kb | Distal (>10kb) Multiome | 970 | |
| chr14:24,171,489–24,172,698 | 142 bp | At TSS Multiome | 365 | |
| chr14:24,188,229–24,189,111 | 16.8 kb | Distal (>10kb) Multiome | 1074 | |
| chr14:24,195,072–24,196,365 | 23.6 kb | Distal (>10kb) Multiome | 1059 | |
| chr14:24,212,871–24,213,884 | 41.4 kb | Distal (>10kb) Multiome | 1036 | |
| chr14:24,215,523–24,216,241 | 44.0 kb | Distal (>10kb) Multiome | 955 | |
| chr14:24,231,706–24,233,147 | 60.5 kb | Distal (>10kb) Multiome | 1027 | |
| chr14:24,241,845–24,243,572 | 70.6 kb | Distal (>10kb) Multiome | 1077 | |
| chr14:24,270,770–24,271,924 | 99.4 kb | Distal (>10kb) Multiome | 1089 | |
| chr14:24,299,120–24,300,273 | 127.8 kb | Distal (>10kb) Multiome | 892 | |
| chr14:24,315,948–24,316,753 | 144.4 kb | Distal (>10kb) Multiome | 736 | |
| chr14:24,332,251–24,333,127 | 160.5 kb | Distal (>10kb) Multiome | 740 | |
| chr14:24,365,652–24,366,243 | 193.7 kb | Distal (>10kb) Multiome | 668 | |
| chr14:24,366,594–24,369,358 | 195.2 kb | Distal (>10kb) Multiome | 921 | |
| chr14:24,388,547–24,389,510 | 216.9 kb | Distal (>10kb) Multiome | 161 | |
| chr14:24,398,424–24,399,423 | 226.9 kb | Distal (>10kb) Multiome | 354 | |
| chr14:24,429,597–24,431,070 | 258.1 kb | Distal (>10kb) Multiome | 903 | |
| chr14:24,431,554–24,432,205 | 259.9 kb | Distal (>10kb) Multiome | 604 | |
| chr14:24,441,935–24,443,373 | 270.6 kb | Distal (>10kb) Multiome | 1072 |
Genomic view of the REC8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.