This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for RDH10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RDH10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RDH10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:73,008,165–73,009,389 | 285.8 kb | Distal (>10kb) Multiome | 699 | |
| chr8:73,092,506–73,093,728 | 201.5 kb | Distal (>10kb) Multiome | 249 | |
| chr8:73,174,013–73,174,795 | 120.1 kb | Distal (>10kb) Multiome | 447 | |
| chr8:73,285,133–73,286,577 | 8.8 kb | Proximal (<10kb) Multiome | 282 | |
| chr8:73,293,182–73,296,152 | 416 bp | At TSS Multiome | 1030 | |
| chr8:73,304,283–73,304,706 | 9.7 kb | Proximal (<10kb) | 16 | |
| chr8:73,448,791–73,449,788 | 154.6 kb | Distal (>10kb) Multiome | 239 |
Genomic view of the RDH10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.