This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Transcription factors with Perturb-seq knockdown data for RBSN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBSN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBSN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:14,810,059–14,811,386 | 288.5 kb | Distal (>10kb) Multiome | 162 | |
| chr3:14,847,690–14,848,492 | 251.0 kb | Distal (>10kb) Multiome | 317 | |
| chr3:14,947,039–14,949,016 | 150.7 kb | Distal (>10kb) Multiome | 992 | |
| chr3:15,064,860–15,065,480 | 33.8 kb | Distal (>10kb) Multiome | 832 | |
| chr3:15,098,771–15,099,764 | 14 bp | At TSS Multiome | 1059 | |
| chr3:15,108,173–15,108,539 | 9.0 kb | Proximal (<10kb) | 332 | |
| chr3:15,118,530–15,119,129 | 19.7 kb | Distal (>10kb) Multiome | 281 | |
| chr3:15,305,253–15,306,068 | 206.5 kb | Distal (>10kb) Multiome | 367 | |
| chr3:15,331,772–15,333,155 | 233.5 kb | Distal (>10kb) Multiome | 642 | |
| chr3:15,356,271–15,357,033 | 257.5 kb | Distal (>10kb) Multiome | 98 | |
| chr3:15,377,980–15,378,549 | 279.2 kb | Distal (>10kb) Multiome | 575 |
Genomic view of the RBSN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.