This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for RBM5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:49,802,203–49,804,006 | 286.1 kb | Distal (>10kb) Multiome | 733 | |
| chr3:49,856,099–49,857,163 | 232.3 kb | Distal (>10kb) Multiome | 664 | |
| chr3:49,869,590–49,870,249 | 219.0 kb | Distal (>10kb) Multiome | 251 | |
| chr3:49,903,411–49,904,277 | 185.0 kb | Distal (>10kb) Multiome | 415 | |
| chr3:49,929,290–49,930,212 | 159.2 kb | Distal (>10kb) Multiome | 799 | |
| chr3:49,939,635–49,940,747 | 148.9 kb | Distal (>10kb) Multiome | 949 | |
| chr3:50,088,748–50,089,596 | 33 bp | At TSS Multiome | 677 | |
| chr3:50,121,279–50,122,037 | 32.8 kb | Distal (>10kb) Multiome | 364 | |
| chr3:50,138,509–50,140,035 | 50.4 kb | Distal (>10kb) Multiome | 198 | |
| chr3:50,154,437–50,155,741 | 66.1 kb | Distal (>10kb) Multiome | 450 | |
| chr3:50,204,913–50,205,545 | 116.3 kb | Distal (>10kb) Multiome | 367 | |
| chr3:50,205,645–50,206,357 | 117.2 kb | Distal (>10kb) Multiome | 347 | |
| chr3:50,226,120–50,228,328 | 137.3 kb | Distal (>10kb) Multiome | 915 | |
| chr3:50,235,551–50,236,824 | 147.1 kb | Distal (>10kb) Multiome | 632 | |
| chr3:50,240,985–50,241,805 | 152.3 kb | Distal (>10kb) Multiome | 137 | |
| chr3:50,245,721–50,247,161 | 157.3 kb | Distal (>10kb) Multiome | 671 | |
| chr3:50,259,568–50,260,922 | 171.3 kb | Distal (>10kb) Multiome | 869 | |
| chr3:50,264,309–50,265,446 | 175.9 kb | Distal (>10kb) Multiome | 568 | |
| chr3:50,275,163–50,276,639 | 187.5 kb | Distal (>10kb) Multiome | 151 | |
| chr3:50,291,628–50,292,796 | 203.6 kb | Distal (>10kb) Multiome | 855 | |
| chr3:50,298,495–50,300,110 | 210.5 kb | Distal (>10kb) Multiome | 872 | |
| chr3:50,303,363–50,303,840 | 214.7 kb | Distal (>10kb) Multiome | 484 | |
| chr3:50,320,603–50,322,739 | 232.6 kb | Distal (>10kb) Multiome | 816 | |
| chr3:50,324,456–50,325,020 | 235.8 kb | Distal (>10kb) Multiome | 392 | |
| chr3:50,327,933–50,328,581 | 239.3 kb | Distal (>10kb) Multiome | 697 | |
| chr3:50,336,856–50,338,227 | 248.6 kb | Distal (>10kb) Multiome | 952 | |
| chr3:50,340,624–50,341,322 | 252.0 kb | Distal (>10kb) Multiome | 345 | |
| chr3:50,345,443–50,346,042 | 256.8 kb | Distal (>10kb) Multiome | 209 | |
| chr3:50,350,496–50,351,298 | 262.0 kb | Distal (>10kb) Multiome | 902 | |
| chr3:50,358,889–50,360,012 | 270.6 kb | Distal (>10kb) Multiome | 796 | |
| chr3:50,364,552–50,365,867 | 276.3 kb | Distal (>10kb) Multiome | 331 |
Genomic view of the RBM5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.