Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
Transcription factors with Perturb-seq knockdown data for RBM15B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM15B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM15B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:50,350,496–50,351,298 | 1040.3 kb | Distal (>10kb) Multiome HiCAR | 902 | |
| chr3:50,358,889–50,360,012 | 1031.7 kb | Distal (>10kb) Multiome HiCAR | 796 | |
| chr3:50,502,505–50,504,160 | 887.6 kb | Distal (>10kb) Multiome HiCAR | 312 | |
| chr3:50,611,315–50,612,530 | 779.3 kb | Distal (>10kb) Multiome HiCAR | 904 | |
| chr3:50,615,997–50,617,867 | 774.2 kb | Distal (>10kb) Multiome HiCAR | 754 | |
| chr3:50,674,463–50,675,603 | 716.1 kb | Distal (>10kb) Multiome HiCAR | 344 | |
| chr3:51,384,278–51,385,586 | 6.2 kb | Proximal (<10kb) Multiome | 787 | |
| chr3:51,389,434–51,389,637 | 1.6 kb | Proximal (<10kb) | 189 | |
| chr3:51,390,699–51,392,749 | 123 bp | At TSS Multiome | 824 | |
| chr3:51,499,159–51,500,640 | 108.8 kb | Distal (>10kb) Multiome | 838 | |
| chr3:51,538,310–51,539,294 | 147.4 kb | Distal (>10kb) Multiome | 974 | |
| chr3:51,670,855–51,672,297 | 279.9 kb | Distal (>10kb) Multiome HiCAR | 799 | |
| chr3:51,681,945–51,682,394 | 291.0 kb | Distal (>10kb) Multiome HiCAR | 291 |
Genomic view of the RBM15B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.