Transcription factors with Perturb-seq knockdown data for RBM15-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM15-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM15-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:110,067,875–110,068,495 | 271.1 kb | Distal (>10kb) Multiome | 113 | |
| chr1:110,068,868–110,070,694 | 268.5 kb | Distal (>10kb) Multiome | 149 | |
| chr1:110,106,008–110,106,637 | 232.8 kb | Distal (>10kb) Multiome | 311 | |
| chr1:110,150,271–110,151,323 | 188.3 kb | Distal (>10kb) Multiome | 278 | |
| chr1:110,209,629–110,212,414 | 129.0 kb | Distal (>10kb) Multiome | 639 | |
| chr1:110,312,453–110,313,110 | 26.3 kb | Distal (>10kb) Multiome | 331 | |
| chr1:110,337,715–110,340,405 | 27 bp | At TSS Multiome | 1136 | |
| chr1:110,407,200–110,408,209 | 68.6 kb | Distal (>10kb) Multiome | 1029 | |
| chr1:110,555,155–110,555,934 | 216.4 kb | Distal (>10kb) Multiome | 301 | |
| chr1:110,605,925–110,607,725 | 267.3 kb | Distal (>10kb) Multiome | 300 | |
| chr1:110,619,278–110,620,032 | 280.4 kb | Distal (>10kb) Multiome | 443 |
Genomic view of the RBM15-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.