RBM15

RNA binding motif protein 15 | OTT, OTT1

Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

Member of: DE-6

Biological processes 28 terms

RNA N6-methyladenosine methyltransferase complex (GO:0036396)RNA N6-methyladenosine methyltransferase complex (GO:0036396)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA binding (GO:0003723)RNA methylation (GO:0001510)dosage compensation by inactivation of X chromosome (GO:0009048)dosage compensation by inactivation of X chromosome (GO:0009048)mRNA binding (GO:0003729)mRNA binding (GO:0003729)negative regulation of DNA-templated transcription (GO:0045892)nuclear envelope (GO:0005635)nuclear membrane (GO:0031965)nuclear speck (GO:0016607)nuclear speck (GO:0016607)nucleic acid binding (GO:0003676)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of alternative mRNA splicing, via spliceosome (GO:0000381)regulation of alternative mRNA splicing, via spliceosome (GO:0000381)regulation of alternative mRNA splicing, via spliceosome (GO:0000381)regulation of megakaryocyte differentiation (GO:0045652)regulation of myeloid cell differentiation (GO:0045637)thrombopoietin-mediated signaling pathway (GO:0038163)thrombopoietin-mediated signaling pathway (GO:0038163)

Expression (TPM)

TFs regulating RBM15 0 TFs

Transcription factors with Perturb-seq knockdown data for RBM15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RBM15

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:110,067,875–110,068,495	271.3 kb	Distal (>10kb) Multiome	113
chr1:110,068,868–110,070,694	268.8 kb	Distal (>10kb) Multiome	149
chr1:110,106,008–110,106,637	233.2 kb	Distal (>10kb) Multiome	311
chr1:110,134,868–110,135,830	204.0 kb	Distal (>10kb) Multiome	133
chr1:110,150,271–110,151,323	188.8 kb	Distal (>10kb) Multiome	278
chr1:110,209,629–110,212,414	129.3 kb	Distal (>10kb) Multiome HiCAR	639
chr1:110,300,420–110,301,012	38.8 kb	Distal (>10kb) Multiome	100
chr1:110,312,453–110,313,110	26.7 kb	Distal (>10kb) Multiome	331
chr1:110,337,715–110,340,405	348 bp	At TSS Multiome	1136
chr1:110,407,200–110,408,209	68.3 kb	Distal (>10kb) Multiome	1029
chr1:110,555,155–110,555,934	216.0 kb	Distal (>10kb) Multiome	301
chr1:110,605,925–110,607,725	267.1 kb	Distal (>10kb) Multiome	300
chr1:110,619,278–110,620,032	280.1 kb	Distal (>10kb) Multiome	443

Genome Browser

Genomic view of the RBM15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.