Involved in ribosome biogenesis. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RBIS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBIS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBIS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:85,106,583–85,108,304 | 113.1 kb | Distal (>10kb) Multiome | 759 | |
| chr8:85,176,569–85,178,114 | 43.1 kb | Distal (>10kb) Multiome | 922 | |
| chr8:85,219,878–85,221,874 | 135 bp | At TSS Multiome | 895 | |
| chr8:85,244,896–85,246,268 | 25.3 kb | Distal (>10kb) Multiome | 796 | |
| chr8:85,463,010–85,465,876 | 243.4 kb | Distal (>10kb) Multiome | 649 |
Genomic view of the RBIS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.