Transcription factors with Perturb-seq knockdown data for RASSF8-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RASSF8-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RASSF8-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:25,876,360–25,876,912 | 81.9 kb | Distal (>10kb) Multiome | 39 | |
| chr12:25,958,056–25,959,417 | 68 bp | At TSS Multiome | 529 | |
| chr12:26,065,293–26,065,889 | 107.1 kb | Distal (>10kb) Multiome | 70 | |
| chr12:26,088,833–26,089,365 | 130.5 kb | Distal (>10kb) Multiome | 80 | |
| chr12:26,113,933–26,115,170 | 155.9 kb | Distal (>10kb) Multiome | 955 | |
| chr12:26,121,816–26,123,629 | 164.1 kb | Distal (>10kb) Multiome | 439 | |
| chr12:26,124,811–26,126,830 | 168.0 kb | Distal (>10kb) Multiome | 661 | |
| chr12:26,195,307–26,196,297 | 237.2 kb | Distal (>10kb) Multiome | 353 |
Genomic view of the RASSF8-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.