This gene encodes a protein that contains a Ras association domain. Similar to its cattle and sheep counterparts, this gene is located near the prion gene. Two alternatively spliced transcripts encoding the same isoform have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RASSF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RASSF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RASSF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:4,686,164–4,687,524 | 137.2 kb | Distal (>10kb) Multiome | 850 | |
| chr20:4,760,641–4,761,305 | 62.7 kb | Distal (>10kb) Multiome | 682 | |
| chr20:4,822,174–4,824,353 | 67 bp | At TSS Multiome | 588 | |
| chr20:5,000,957–5,002,039 | 178.0 kb | Distal (>10kb) Multiome | 553 | |
| chr20:5,112,796–5,113,601 | 289.6 kb | Distal (>10kb) Multiome | 1034 | |
| chr20:5,119,153–5,120,492 | 296.4 kb | Distal (>10kb) Multiome | 1100 |
Genomic view of the RASSF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.