RASIP1
Ras interacting protein 1 | FLJ20401, RAIN

Enables GTPase binding activity and protein homodimerization activity. Involved in several processes, including negative regulation of Rho protein signal transduction; negative regulation of metabolic process; and positive regulation of integrin activation. Located in cell-cell junction. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 23 terms
GTPase binding (GO:0051020)GTPase binding (GO:0051020)Golgi stack (GO:0005795)angiogenesis (GO:0001525)angiogenesis (GO:0001525)angiogenesis (GO:0001525)branching morphogenesis of an epithelial tube (GO:0048754)branching morphogenesis of an epithelial tube (GO:0048754)cell-cell junction (GO:0005911)cell-cell junction (GO:0005911)negative regulation of Rho protein signal transduction (GO:0035024)negative regulation of Rho protein signal transduction (GO:0035024)negative regulation of autophagy (GO:0010507)negative regulation of membrane permeability (GO:1905709)perinuclear region of cytoplasm (GO:0048471)positive regulation of integrin activation (GO:0033625)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein serine/threonine kinase inhibitor activity (GO:0030291)protein-containing complex (GO:0032991)signal transduction (GO:0007165)vasculogenesis (GO:0001570)vasculogenesis (GO:0001570)
Expression (TPM)
RASIP1 — as a Regulated Gene

TFs regulating RASIP1 0 TFs

Transcription factors with Perturb-seq knockdown data for RASIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RASIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RASIP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RASIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:48,445,379–48,446,456 293.1 kb Distal (>10kb) Multiome 845
chr19:48,468,758–48,470,027 269.9 kb Distal (>10kb) Multiome 860
chr19:48,490,661–48,494,449 245.8 kb Distal (>10kb) Multiome 633
chr19:48,500,898–48,503,050 237.0 kb Distal (>10kb) Multiome 656
chr19:48,510,624–48,511,212 228.3 kb Distal (>10kb) Multiome 268
chr19:48,513,480–48,514,294 225.1 kb Distal (>10kb) Multiome 585
chr19:48,614,318–48,615,255 124.1 kb Distal (>10kb) Multiome 524
chr19:48,618,726–48,619,869 119.7 kb Distal (>10kb) Multiome 1012
chr19:48,623,839–48,624,688 114.8 kb Distal (>10kb) Multiome 529
chr19:48,629,369–48,631,306 109.0 kb Distal (>10kb) Multiome 402
chr19:48,634,242–48,636,244 104.4 kb Distal (>10kb) Multiome 868
chr19:48,636,802–48,639,603 101.3 kb Distal (>10kb) Multiome 956
chr19:48,645,454–48,647,163 92.5 kb Distal (>10kb) Multiome 750
chr19:48,675,421–48,675,873 63.5 kb Distal (>10kb) Multiome 415
chr19:48,695,830–48,697,033 42.9 kb Distal (>10kb) Multiome 253
chr19:48,713,646–48,714,846 24.7 kb Distal (>10kb) Multiome 719
chr19:48,716,551–48,717,038 22.1 kb Distal (>10kb) Multiome 241
chr19:48,720,420–48,721,301 18.1 kb Distal (>10kb) Multiome 689
chr19:48,728,887–48,729,334 9.7 kb Proximal (<10kb) 111
chr19:48,735,001–48,735,602 3.8 kb Proximal (<10kb) Multiome 161
chr19:48,737,434–48,737,704 1.3 kb Proximal (<10kb) 172
chr19:48,738,441–48,739,812 111 bp At TSS Multiome 743
chr19:48,741,194–48,741,939 2.6 kb Proximal (<10kb) Multiome 350
chr19:48,745,316–48,745,509 6.3 kb Proximal (<10kb) 231
chr19:48,746,830–48,747,395 8.1 kb Proximal (<10kb) Multiome 402
chr19:48,752,314–48,753,547 13.9 kb Distal (>10kb) Multiome 545
chr19:48,795,165–48,795,736 56.5 kb Distal (>10kb) Multiome 724
chr19:48,806,734–48,807,478 67.9 kb Distal (>10kb) Multiome 452
chr19:48,810,774–48,811,494 72.0 kb Distal (>10kb) Multiome 662
chr19:48,812,048–48,813,099 73.5 kb Distal (>10kb) Multiome 603
chr19:48,835,571–48,838,073 98.2 kb Distal (>10kb) Multiome 621
chr19:48,872,000–48,873,835 133.3 kb Distal (>10kb) Multiome 987
chr19:48,895,958–48,896,628 157.3 kb Distal (>10kb) Multiome 207
chr19:48,899,782–48,900,620 161.2 kb Distal (>10kb) Multiome 710
chr19:48,933,397–48,933,948 194.6 kb Distal (>10kb) Multiome 458
chr19:48,954,440–48,955,356 215.8 kb Distal (>10kb) Multiome 905
chr19:48,963,322–48,964,187 224.8 kb Distal (>10kb) Multiome 866
chr19:48,964,515–48,966,446 226.2 kb Distal (>10kb) Multiome 1015
chr19:48,992,571–48,994,129 254.5 kb Distal (>10kb) Multiome 852
chr19:49,017,642–49,018,292 278.9 kb Distal (>10kb) Multiome 480
chr19:49,019,277–49,019,889 280.6 kb Distal (>10kb) Multiome 233

Genome Browser

Genomic view of the RASIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:48,435,379 – 49,029,889
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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