The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Transcription factors with Perturb-seq knockdown data for RASA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RASA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RASA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:141,231,050–141,232,888 | 255.3 kb | Distal (>10kb) Multiome | 693 | |
| chr3:141,311,338–141,312,269 | 175.2 kb | Distal (>10kb) Multiome | 905 | |
| chr3:141,393,230–141,393,880 | 93.6 kb | Distal (>10kb) Multiome | 267 | |
| chr3:141,401,959–141,403,068 | 84.5 kb | Distal (>10kb) Multiome | 621 | |
| chr3:141,486,398–141,488,045 | 41 bp | At TSS Multiome | 864 | |
| chr3:141,737,813–141,739,101 | 251.2 kb | Distal (>10kb) Multiome | 924 | |
| chr3:141,796,843–141,798,274 | 310.4 kb | Distal (>10kb) Multiome | 349 | |
| chr3:141,875,535–141,877,500 | 389.6 kb | Distal (>10kb) Multiome | 796 |
Genomic view of the RASA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.