Transcription factors with Perturb-seq knockdown data for RAP2C-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAP2C-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAP2C-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:131,830,409–131,831,150 | 387.4 kb | Distal (>10kb) Multiome HiCAR | 630 | |
| chrX:132,022,650–132,024,225 | 195.0 kb | Distal (>10kb) Multiome | 634 | |
| chrX:132,217,117–132,218,510 | 697 bp | At TSS Multiome | 709 | |
| chrX:132,219,377–132,219,602 | 1.2 kb | Proximal (<10kb) | 366 | |
| chrX:132,489,302–132,490,128 | 271.5 kb | Distal (>10kb) Multiome | 444 |
Genomic view of the RAP2C-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.