This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RANBP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RANBP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RANBP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:5,679,757–5,681,464 | 297.3 kb | Distal (>10kb) Multiome | 884 | |
| chr19:5,686,329–5,687,994 | 291.1 kb | Distal (>10kb) Multiome | 693 | |
| chr19:5,689,735–5,690,874 | 287.8 kb | Distal (>10kb) Multiome | 960 | |
| chr19:5,719,717–5,721,174 | 257.7 kb | Distal (>10kb) Multiome | 985 | |
| chr19:5,790,527–5,791,509 | 187.2 kb | Distal (>10kb) Multiome | 965 | |
| chr19:5,803,750–5,806,128 | 172.9 kb | Distal (>10kb) Multiome | 858 | |
| chr19:5,826,528–5,829,726 | 150.0 kb | Distal (>10kb) Multiome | 1037 | |
| chr19:5,903,474–5,905,358 | 73.5 kb | Distal (>10kb) Multiome | 1027 | |
| chr19:5,968,047–5,968,198 | 9.9 kb | Proximal (<10kb) | 329 | |
| chr19:5,977,406–5,978,787 | 115 bp | At TSS Multiome | 1028 | |
| chr19:6,110,281–6,110,936 | 132.6 kb | Distal (>10kb) Multiome | 518 | |
| chr19:6,199,134–6,200,121 | 221.6 kb | Distal (>10kb) Multiome | 769 |
Genomic view of the RANBP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.