RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RANBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RANBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RANBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:108,448,417–108,449,710 | 270.4 kb | Distal (>10kb) Multiome | 999 | |
| chr2:108,533,404–108,535,229 | 185.2 kb | Distal (>10kb) Multiome | 1035 | |
| chr2:108,583,732–108,584,281 | 135.4 kb | Distal (>10kb) Multiome | 283 | |
| chr2:108,608,990–108,609,565 | 110.1 kb | Distal (>10kb) Multiome | 125 | |
| chr2:108,620,806–108,621,587 | 98.3 kb | Distal (>10kb) Multiome | 401 | |
| chr2:108,636,177–108,636,884 | 83.0 kb | Distal (>10kb) Multiome | 398 | |
| chr2:108,718,922–108,720,037 | 21 bp | At TSS Multiome | 1042 | |
| chr2:108,786,273–108,787,203 | 67.3 kb | Distal (>10kb) Multiome | 874 |
Genomic view of the RANBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.