Enables RNA binding activity and enzyme activator activity. Involved in 7-methylguanosine mRNA capping. Located in nucleus. Part of mRNA cap methyltransferase RNMT:RAMAC complex and mRNA capping enzyme complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RAMAC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAMAC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAMAC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:82,708,766–82,710,416 | 276.5 kb | Distal (>10kb) Multiome | 725 | |
| chr15:82,750,200–82,750,777 | 235.7 kb | Distal (>10kb) Multiome | 790 | |
| chr15:82,809,212–82,810,601 | 176.5 kb | Distal (>10kb) Multiome | 808 | |
| chr15:82,849,476–82,850,366 | 136.3 kb | Distal (>10kb) Multiome HiCAR | 450 | |
| chr15:82,910,611–82,911,202 | 75.2 kb | Distal (>10kb) Multiome | 35 | |
| chr15:82,952,161–82,953,316 | 33.4 kb | Distal (>10kb) Multiome | 430 | |
| chr15:82,985,830–82,986,497 | 71 bp | At TSS Multiome | 853 | |
| chr15:83,010,925–83,012,341 | 25.5 kb | Distal (>10kb) Multiome | 964 | |
| chr15:83,066,587–83,067,782 | 81.0 kb | Distal (>10kb) Multiome | 877 | |
| chr15:83,106,916–83,108,096 | 121.1 kb | Distal (>10kb) Multiome | 392 | |
| chr15:83,143,995–83,145,038 | 158.1 kb | Distal (>10kb) Multiome | 146 | |
| chr15:83,178,820–83,179,295 | 192.8 kb | Distal (>10kb) Multiome | 114 | |
| chr15:83,206,651–83,208,545 | 222.0 kb | Distal (>10kb) Multiome | 607 |
Genomic view of the RAMAC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.