Enables guanyl-nucleotide exchange factor activity. Involved in regulation of Ral protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for RALGPS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RALGPS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RALGPS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:126,638,337–126,639,289 | 275.9 kb | Distal (>10kb) Multiome | 121 | |
| chr9:126,642,527–126,643,462 | 271.7 kb | Distal (>10kb) Multiome | 236 | |
| chr9:126,651,890–126,653,007 | 262.4 kb | Distal (>10kb) Multiome | 194 | |
| chr9:126,661,485–126,662,054 | 253.0 kb | Distal (>10kb) Multiome | 301 | |
| chr9:126,664,997–126,665,774 | 249.4 kb | Distal (>10kb) Multiome | 206 | |
| chr9:126,676,328–126,677,650 | 237.8 kb | Distal (>10kb) Multiome | 280 | |
| chr9:126,702,378–126,702,753 | 212.0 kb | Distal (>10kb) Multiome | 106 | |
| chr9:126,705,159–126,705,769 | 209.3 kb | Distal (>10kb) Multiome | 410 | |
| chr9:126,722,279–126,723,703 | 192.2 kb | Distal (>10kb) Multiome | 486 | |
| chr9:126,781,625–126,782,080 | 132.9 kb | Distal (>10kb) Multiome | 311 | |
| chr9:126,804,620–126,805,548 | 109.7 kb | Distal (>10kb) Multiome | 787 | |
| chr9:126,860,094–126,861,384 | 54.2 kb | Distal (>10kb) Multiome | 736 | |
| chr9:126,914,361–126,916,118 | 249 bp | At TSS Multiome | 602 | |
| chr9:126,917,040–126,917,217 | 2.3 kb | Proximal (<10kb) | 49 | |
| chr9:127,027,806–127,028,318 | 113.2 kb | Distal (>10kb) Multiome | 28 | |
| chr9:127,111,996–127,112,450 | 197.5 kb | Distal (>10kb) Multiome | 160 | |
| chr9:127,122,192–127,123,298 | 208.1 kb | Distal (>10kb) Multiome | 426 | |
| chr9:127,129,382–127,130,064 | 214.9 kb | Distal (>10kb) Multiome | 117 | |
| chr9:127,199,063–127,199,676 | 284.6 kb | Distal (>10kb) Multiome HiCAR | 315 |
Genomic view of the RALGPS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.