The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for RAD51B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAD51B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAD51B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:67,532,784–67,533,987 | 286.5 kb | Distal (>10kb) Multiome | 684 | |
| chr14:67,541,829–67,542,290 | 277.8 kb | Distal (>10kb) Multiome | 187 | |
| chr14:67,599,595–67,600,617 | 219.6 kb | Distal (>10kb) Multiome | 746 | |
| chr14:67,619,336–67,620,756 | 200.0 kb | Distal (>10kb) Multiome | 794 | |
| chr14:67,674,148–67,675,415 | 145.0 kb | Distal (>10kb) Multiome | 840 | |
| chr14:67,694,763–67,695,985 | 125.0 kb | Distal (>10kb) Multiome | 742 | |
| chr14:67,729,052–67,729,527 | 90.5 kb | Distal (>10kb) Multiome | 407 | |
| chr14:67,816,043–67,817,024 | 3.2 kb | Proximal (<10kb) Multiome | 712 | |
| chr14:67,819,625–67,820,281 | at TSS | At TSS Multiome | 482 | |
| chr14:67,934,038–67,934,596 | 114.5 kb | Distal (>10kb) Multiome | 380 | |
| chr14:68,628,283–68,629,329 | 808.7 kb | Distal (>10kb) Multiome HiCAR | 311 | |
| chr14:68,762,791–68,763,528 | 943.3 kb | Distal (>10kb) Multiome HiCAR | 389 | |
| chr14:68,790,871–68,793,970 | 973.5 kb | Distal (>10kb) Multiome HiCAR | 866 | |
| chr14:68,794,853–68,797,758 | 976.3 kb | Distal (>10kb) Multiome HiCAR | 1023 | |
| chr14:68,816,186–68,816,983 | 996.9 kb | Distal (>10kb) Multiome HiCAR | 816 |
Genomic view of the RAD51B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.