RAC1

RAC1

Rac family small GTPase 1 | Rac-1, TC-25, p21-Rac1

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Member of: DE-1 DE-1.33

Biological processes 148 terms

G protein activity (GO:0003925)G protein activity (GO:0003925)GTP binding (GO:0005525)GTP binding (GO:0005525)GTP binding (GO:0005525)GTP binding (GO:0005525)GTP-dependent protein binding (GO:0030742)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase activity (GO:0003924)NADPH oxidase complex (GO:0043020)Rac protein signal transduction (GO:0016601)Rac protein signal transduction (GO:0016601)Rac protein signal transduction (GO:0016601)Rho GDP-dissociation inhibitor binding (GO:0051022)Wnt signaling pathway, planar cell polarity pathway (GO:0060071)actin cytoskeleton organization (GO:0030036)actin filament (GO:0005884)actin filament organization (GO:0007015)actin filament organization (GO:0007015)actin filament polymerization (GO:0030041)anatomical structure morphogenesis (GO:0009653)cell adhesion (GO:0007155)cell chemotaxis (GO:0060326)cell cortex (GO:0005938)cell cortex (GO:0005938)cell migration (GO:0016477)cell migration (GO:0016477)cell motility (GO:0048870)cell projection (GO:0042995)cell projection assembly (GO:0030031)cell-matrix adhesion (GO:0007160)cell-matrix adhesion (GO:0007160)cortical cytoskeleton organization (GO:0030865)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic ribonucleoprotein granule (GO:0036464)cytoplasmic vesicle (GO:0031410)cytoplasmic vesicle (GO:0031410)cytoskeleton (GO:0005856)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)dendrite (GO:0030425)early endosome membrane (GO:0031901)endoplasmic reticulum membrane (GO:0005789)engulfment of apoptotic cell (GO:0043652)enzyme binding (GO:0019899)enzyme-linked receptor protein signaling pathway (GO:0007167)establishment or maintenance of cell polarity (GO:0007163)extracellular exosome (GO:0070062)ficolin-1-rich granule membrane (GO:0101003)focal adhesion (GO:0005925)forebrain development (GO:0030900)glutamatergic synapse (GO:0098978)glutamatergic synapse (GO:0098978)glutamatergic synapse (GO:0098978)hepatocyte growth factor receptor signaling pathway (GO:0048012)inflammatory response (GO:0006954)intracellular signal transduction (GO:0035556)kinocilium (GO:0060091)lamellipodium (GO:0030027)lamellipodium (GO:0030027)lamellipodium assembly (GO:0030032)localization within membrane (GO:0051668)melanosome (GO:0042470)membrane (GO:0016020)membrane (GO:0016020)midbrain dopaminergic neuron differentiation (GO:1904948)motor neuron axon guidance (GO:0008045)negative regulation of fibroblast migration (GO:0010764)negative regulation of interleukin-23 production (GO:0032707)negative regulation of receptor-mediated endocytosis (GO:0048261)neuron migration (GO:0001764)neuron migration (GO:0001764)neuron projection morphogenesis (GO:0048812)non-canonical Wnt signaling pathway (GO:0035567)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)pericentriolar material (GO:0000242)phagocytic cup (GO:0001891)phagocytosis, engulfment (GO:0006911)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of Rho protein signal transduction (GO:0035025)positive regulation of bicellular tight junction assembly (GO:1903348)positive regulation of endothelial cell migration (GO:0010595)positive regulation of focal adhesion assembly (GO:0051894)positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0035774)positive regulation of lamellipodium assembly (GO:0010592)positive regulation of lamellipodium assembly (GO:0010592)positive regulation of neutrophil chemotaxis (GO:0090023)positive regulation of neutrophil chemotaxis (GO:0090023)positive regulation of ovarian follicle development (GO:2000386)positive regulation of protein phosphorylation (GO:0001934)positive regulation of ruffle assembly (GO:1900029)positive regulation of stress fiber assembly (GO:0051496)positive regulation of stress fiber assembly (GO:0051496)positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)postsynapse (GO:0098794)postsynapse (GO:0098794)postsynaptic membrane (GO:0045211)presynaptic membrane (GO:0042734)protein binding (GO:0005515)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein-containing complex binding (GO:0044877)recycling endosome membrane (GO:0055038)regulation of actin cytoskeleton organization (GO:0032956)regulation of cell adhesion involved in heart morphogenesis (GO:0061344)regulation of cell migration (GO:0030334)regulation of cell shape (GO:0008360)regulation of cell-substrate adhesion (GO:0010810)regulation of fibroblast migration (GO:0010762)regulation of hydrogen peroxide metabolic process (GO:0010310)regulation of lamellipodium assembly (GO:0010591)regulation of neutrophil migration (GO:1902622)regulation of nitric oxide biosynthetic process (GO:0045428)regulation of postsynapse assembly (GO:0150052)regulation of receptor signaling pathway via JAK-STAT (GO:0046425)regulation of respiratory burst (GO:0060263)regulation of stress fiber assembly (GO:0051492)regulation of synaptic vesicle endocytosis (GO:1900242)respiratory burst (GO:0045730)response to lipopolysaccharide (GO:0032496)response to wounding (GO:0009611)ruffle assembly (GO:0097178)ruffle assembly (GO:0097178)ruffle membrane (GO:0032587)ruffle membrane (GO:0032587)ruffle organization (GO:0031529)secretory granule membrane (GO:0030667)semaphorin-plexin signaling pathway (GO:0071526)small GTPase-mediated signal transduction (GO:0007264)small GTPase-mediated signal transduction (GO:0007264)sphingosine-1-phosphate receptor signaling pathway (GO:0003376)substrate adhesion-dependent cell spreading (GO:0034446)superoxide anion generation (GO:0042554)synapse (GO:0045202)synaptic vesicle membrane (GO:0030672)thioesterase binding (GO:0031996)trans-Golgi network (GO:0005802)

Expression (TPM)

TFs regulating RAC1 0 TFs

Transcription factors with Perturb-seq knockdown data for RAC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RAC1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr7:6,081,109–6,081,851	293.0 kb	Distal (>10kb) Multiome	904
	chr7:6,103,982–6,105,662	269.7 kb	Distal (>10kb) Multiome	1040
	chr7:6,271,933–6,273,059	101.9 kb	Distal (>10kb) Multiome	582
	chr7:6,348,284–6,349,527	25.6 kb	Distal (>10kb) Multiome	787
	chr7:6,374,107–6,375,074	105 bp	At TSS Multiome	778
	chr7:6,447,046–6,448,661	73.5 kb	Distal (>10kb) Multiome	944
	chr7:6,483,337–6,484,560	109.7 kb	Distal (>10kb) Multiome	748
	chr7:6,502,814–6,505,187	129.6 kb	Distal (>10kb) Multiome	573
	chr7:6,516,399–6,516,954	142.0 kb	Distal (>10kb) Multiome	245
	chr7:6,526,260–6,527,132	152.2 kb	Distal (>10kb) Multiome	313
	chr7:6,530,620–6,531,774	156.7 kb	Distal (>10kb) Multiome	296
	chr7:6,536,237–6,537,265	162.4 kb	Distal (>10kb) Multiome	223
	chr7:6,577,282–6,577,787	202.9 kb	Distal (>10kb) Multiome	840
	chr7:6,589,551–6,590,781	215.5 kb	Distal (>10kb) Multiome	802
	chr7:6,614,875–6,616,376	240.9 kb	Distal (>10kb) Multiome	610
	chr7:6,640,237–6,641,084	266.1 kb	Distal (>10kb) Multiome	238
	chr7:6,663,809–6,664,686	289.5 kb	Distal (>10kb) Multiome	232

Genome Browser

Genomic view of the RAC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.