This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for RABGGTB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RABGGTB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RABGGTB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:75,587,198–75,588,494 | 198.3 kb | Distal (>10kb) Multiome | 154 | |
| chr1:75,614,480–75,617,289 | 171.4 kb | Distal (>10kb) Multiome | 747 | |
| chr1:75,723,970–75,725,189 | 61.7 kb | Distal (>10kb) Multiome | 977 | |
| chr1:75,785,017–75,785,180 | 1.0 kb | Proximal (<10kb) | 155 | |
| chr1:75,785,522–75,786,824 | 38 bp | At TSS Multiome | 835 | |
| chr1:75,795,746–75,799,043 | 9.5 kb | Proximal (<10kb) | 629 | |
| chr1:76,074,255–76,075,430 | 288.5 kb | Distal (>10kb) Multiome | 452 | |
| chr1:77,218,739–77,219,613 | 1433.2 kb | Distal (>10kb) Multiome HiCAR | 706 |
Genomic view of the RABGGTB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.