Enables myosin V binding activity. Involved in Golgi organization and protein localization to Golgi membrane. Located in Golgi membrane; ciliary basal body; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RAB6B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB6B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB6B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:133,661,440–133,662,508 | 233.9 kb | Distal (>10kb) Multiome | 728 | |
| chr3:133,805,616–133,806,520 | 90.0 kb | Distal (>10kb) Multiome | 710 | |
| chr3:133,894,751–133,896,433 | 54 bp | At TSS Multiome | 424 | |
| chr3:133,927,020–133,928,082 | 31.8 kb | Distal (>10kb) Multiome | 363 | |
| chr3:133,988,622–133,989,245 | 93.1 kb | Distal (>10kb) Multiome | 246 | |
| chr3:134,028,965–134,030,691 | 134.2 kb | Distal (>10kb) Multiome | 495 |
Genomic view of the RAB6B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.