RAB4B

RAB4B, member RAS oncogene family | FLJ78649, MGC52123

Enables GTPase activity. Involved in D-glucose import; early endosome to Golgi transport; and endosomal vesicle fusion. Located in insulin-responsive compartment; perinuclear region of cytoplasm; and recycling endosome. Is active in early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC6

Biological processes 26 terms

D-glucose import across plasma membrane (GO:0098708)G protein activity (GO:0003925)G protein activity (GO:0003925)GTP binding (GO:0005525)GTP binding (GO:0005525)GTPase activity (GO:0003924)GTPase activity (GO:0003924)GTPase activity (GO:0003924)Rab protein signal transduction (GO:0032482)cytoplasmic vesicle membrane (GO:0030659)cytosol (GO:0005829)early endosome membrane (GO:0031901)early endosome membrane (GO:0031901)early endosome to Golgi transport (GO:0034498)endosomal vesicle fusion (GO:0034058)insulin-responsive compartment (GO:0032593)insulin-responsive compartment (GO:0032593)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)recycling endosome (GO:0055037)recycling endosome (GO:0055037)regulation of endocytosis (GO:0030100)secretory granule membrane (GO:0030667)vesicle-mediated transport (GO:0016192)

Expression (TPM)

TFs regulating RAB4B 0 TFs

Transcription factors with Perturb-seq knockdown data for RAB4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RAB4B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:40,487,850–40,488,306	290.2 kb	Distal (>10kb) Multiome	193
chr19:40,519,457–40,519,993	258.6 kb	Distal (>10kb) Multiome	222
chr19:40,528,978–40,529,879	249.0 kb	Distal (>10kb) Multiome	601
chr19:40,529,987–40,530,863	247.6 kb	Distal (>10kb) Multiome	384
chr19:40,549,036–40,549,555	228.9 kb	Distal (>10kb) Multiome	372
chr19:40,570,181–40,571,253	207.5 kb	Distal (>10kb) Multiome	598
chr19:40,576,133–40,577,495	201.4 kb	Distal (>10kb) Multiome	616
chr19:40,596,828–40,597,429	181.2 kb	Distal (>10kb) Multiome	354
chr19:40,598,094–40,598,871	179.7 kb	Distal (>10kb) Multiome	606
chr19:40,603,345–40,604,624	174.2 kb	Distal (>10kb) Multiome	889
chr19:40,604,983–40,606,597	172.5 kb	Distal (>10kb) Multiome	708
chr19:40,609,543–40,610,691	168.2 kb	Distal (>10kb) Multiome	519
chr19:40,612,884–40,615,179	164.6 kb	Distal (>10kb) Multiome	595
chr19:40,623,557–40,624,516	154.2 kb	Distal (>10kb) Multiome	454
chr19:40,634,333–40,634,959	143.7 kb	Distal (>10kb) Multiome	629
chr19:40,662,838–40,663,654	115.2 kb	Distal (>10kb) Multiome	856
chr19:40,689,888–40,691,759	87.5 kb	Distal (>10kb) Multiome	691
chr19:40,714,822–40,715,454	63.1 kb	Distal (>10kb) Multiome	531
chr19:40,716,605–40,717,875	61.2 kb	Distal (>10kb) Multiome	772
chr19:40,750,206–40,751,874	27.5 kb	Distal (>10kb) Multiome	989
chr19:40,777,237–40,779,173	5 bp	At TSS Multiome	901
chr19:40,798,002–40,799,843	20.7 kb	Distal (>10kb) Multiome	936
chr19:40,806,580–40,807,205	28.7 kb	Distal (>10kb) Multiome	496
chr19:40,810,733–40,811,261	32.7 kb	Distal (>10kb) Multiome	115

Genome Browser

Genomic view of the RAB4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.