RAB37
RAB37, member RAS oncogene family

Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM, Apr 2006]

Developmental clusters: GC2
Biological processes 20 terms
G protein activity (GO:0003925)G protein activity (GO:0003925)GTP binding (GO:0005525)GTP binding (GO:0005525)GTPase activity (GO:0003924)GTPase activity (GO:0003924)Golgi apparatus (GO:0005794)azurophil granule membrane (GO:0035577)cilium (GO:0005929)cytoplasmic vesicle (GO:0031410)endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)endosome (GO:0005768)photoreceptor connecting cilium (GO:0032391)plasma membrane (GO:0005886)positive regulation of autophagy (GO:0010508)positive regulation of autophagy (GO:0010508)protein binding (GO:0005515)regulation of exocytosis (GO:0017157)regulation of eye photoreceptor cell development (GO:0042478)specific granule membrane (GO:0035579)
Expression (TPM)
RAB37 — as a Regulated Gene

TFs regulating RAB37 0 TFs

Transcription factors with Perturb-seq knockdown data for RAB37. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB37 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RAB37

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB37, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:74,453,513–74,454,652 283.0 kb Distal (>10kb) Multiome 751
chr17:74,642,311–74,642,966 94.3 kb Distal (>10kb) Multiome 119
chr17:74,643,823–74,644,224 93.0 kb Distal (>10kb) Multiome 17
chr17:74,671,047–74,671,700 65.8 kb Distal (>10kb) Multiome HiCAR 938
chr17:74,736,296–74,738,156 144 bp At TSS Multiome 797
chr17:74,744,666–74,745,585 7.6 kb Proximal (<10kb) Multiome 580
chr17:74,745,827–74,747,102 9.4 kb Proximal (<10kb) Multiome 213
chr17:74,748,109–74,749,683 11.3 kb Distal (>10kb) Multiome 915
chr17:74,775,871–74,776,940 39.1 kb Distal (>10kb) Multiome 798
chr17:74,842,511–74,843,541 105.7 kb Distal (>10kb) Multiome 412
chr17:74,852,259–74,853,211 115.4 kb Distal (>10kb) Multiome 435
chr17:74,872,506–74,873,926 135.9 kb Distal (>10kb) Multiome 1008
chr17:74,893,600–74,894,183 156.5 kb Distal (>10kb) Multiome 189
chr17:74,923,198–74,923,804 186.4 kb Distal (>10kb) Multiome 543
chr17:74,972,019–74,973,116 235.5 kb Distal (>10kb) Multiome 607
chr17:74,982,006–74,982,936 245.2 kb Distal (>10kb) Multiome 952
chr17:74,987,081–74,988,770 250.4 kb Distal (>10kb) Multiome 702
chr17:75,012,158–75,013,285 275.5 kb Distal (>10kb) Multiome 1058
chr17:75,033,550–75,035,757 297.9 kb Distal (>10kb) Multiome 1228

Genome Browser

Genomic view of the RAB37 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:74,443,513 – 75,045,757
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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