The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for RAB2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:60,280,496–60,281,898 | 235.6 kb | Distal (>10kb) Multiome | 626 | |
| chr8:60,352,516–60,353,646 | 163.7 kb | Distal (>10kb) Multiome | 94 | |
| chr8:60,396,070–60,396,507 | 120.6 kb | Distal (>10kb) Multiome | 124 | |
| chr8:60,516,295–60,517,716 | 12 bp | At TSS Multiome | 833 | |
| chr8:60,575,730–60,576,435 | 59.1 kb | Distal (>10kb) Multiome | 231 | |
| chr8:60,651,471–60,652,894 | 135.3 kb | Distal (>10kb) Multiome | 899 | |
| chr8:60,653,001–60,654,152 | 136.8 kb | Distal (>10kb) Multiome | 520 | |
| chr8:60,676,007–60,676,774 | 159.2 kb | Distal (>10kb) Multiome | 159 | |
| chr8:60,678,041–60,680,775 | 161.7 kb | Distal (>10kb) Multiome | 761 |
Genomic view of the RAB2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.