This gene encodes a member of the Rab subfamily of Ras-related small GTPases. The encoded protein may be involved in regulating intracellular trafficking. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 9 and X. [provided by RefSeq, Apr 2009]
Transcription factors with Perturb-seq knockdown data for RAB28. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB28 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB28, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:13,445,640–13,446,865 | 38.2 kb | Distal (>10kb) Multiome | 131 | |
| chr4:13,483,098–13,483,406 | 933 bp | At TSS | 100 | |
| chr4:13,483,568–13,485,391 | 149 bp | At TSS Multiome | 750 | |
| chr4:13,522,245–13,523,548 | 38.4 kb | Distal (>10kb) Multiome | 190 | |
| chr4:13,530,965–13,531,852 | 47.1 kb | Distal (>10kb) Multiome | 173 | |
| chr4:13,540,992–13,542,953 | 57.8 kb | Distal (>10kb) Multiome | 321 | |
| chr4:13,543,269–13,545,468 | 60.7 kb | Distal (>10kb) Multiome | 614 | |
| chr4:13,627,080–13,628,352 | 143.5 kb | Distal (>10kb) Multiome | 934 | |
| chr4:13,654,156–13,655,134 | 170.2 kb | Distal (>10kb) Multiome | 499 |
Genomic view of the RAB28 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.