The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RAB27A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB27A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB27A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:55,196,449–55,197,580 | 122.1 kb | Distal (>10kb) Multiome | 812 | |
| chr15:55,288,999–55,291,001 | 28.6 kb | Distal (>10kb) Multiome | 744 | |
| chr15:55,318,855–55,319,494 | 81 bp | At TSS Multiome | 875 | |
| chr15:55,394,084–55,395,667 | 75.9 kb | Distal (>10kb) Multiome | 153 | |
| chr15:55,407,568–55,409,007 | 89.2 kb | Distal (>10kb) Multiome | 957 | |
| chr15:55,498,088–55,498,593 | 179.3 kb | Distal (>10kb) Multiome | 637 | |
| chr15:55,587,537–55,588,889 | 269.2 kb | Distal (>10kb) Multiome | 432 |
Genomic view of the RAB27A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.