RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]
Transcription factors with Perturb-seq knockdown data for RAB14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RAB14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RAB14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:120,928,372–120,929,413 | 272.9 kb | Distal (>10kb) Multiome | 626 | |
| chr9:121,074,349–121,075,511 | 126.9 kb | Distal (>10kb) Multiome | 1041 | |
| chr9:121,121,551–121,122,082 | 80.1 kb | Distal (>10kb) Multiome | 539 | |
| chr9:121,201,011–121,202,492 | 65 bp | At TSS Multiome | 850 | |
| chr9:121,206,798–121,207,004 | 4.9 kb | Proximal (<10kb) | 73 | |
| chr9:121,221,026–121,221,471 | 19.4 kb | Distal (>10kb) Multiome | 78 | |
| chr9:121,267,686–121,269,264 | 66.2 kb | Distal (>10kb) Multiome | 550 | |
| chr9:121,286,406–121,287,700 | 85.5 kb | Distal (>10kb) Multiome | 735 | |
| chr9:121,299,542–121,300,058 | 97.9 kb | Distal (>10kb) Multiome | 428 | |
| chr9:121,369,661–121,370,788 | 168.5 kb | Distal (>10kb) Multiome | 849 | |
| chr9:121,499,468–121,500,318 | 298.1 kb | Distal (>10kb) Multiome | 361 |
Genomic view of the RAB14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.