Located in exon-exon junction complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for R3HCC1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = R3HCC1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of R3HCC1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:97,849,566–97,850,474 | 284.6 kb | Distal (>10kb) Multiome | 400 | |
| chr10:97,857,830–97,858,402 | 276.6 kb | Distal (>10kb) Multiome | 160 | |
| chr10:97,869,190–97,869,924 | 265.1 kb | Distal (>10kb) Multiome | 506 | |
| chr10:98,029,703–98,031,553 | 103.9 kb | Distal (>10kb) Multiome | 325 | |
| chr10:98,134,300–98,135,354 | 29 bp | At TSS Multiome | 772 | |
| chr10:98,309,066–98,309,892 | 175.0 kb | Distal (>10kb) Multiome | 380 | |
| chr10:98,414,616–98,415,730 | 280.6 kb | Distal (>10kb) Multiome | 701 |
Genomic view of the R3HCC1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.