Predicted to enable nucleic acid binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for R3HCC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = R3HCC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of R3HCC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:22,998,974–23,000,300 | 288.6 kb | Distal (>10kb) Multiome | 597 | |
| chr8:23,019,069–23,020,109 | 268.7 kb | Distal (>10kb) Multiome | 452 | |
| chr8:23,049,698–23,050,409 | 238.1 kb | Distal (>10kb) Multiome | 277 | |
| chr8:23,068,457–23,069,444 | 219.0 kb | Distal (>10kb) Multiome | 856 | |
| chr8:23,083,702–23,084,469 | 203.8 kb | Distal (>10kb) Multiome | 538 | |
| chr8:23,162,920–23,164,386 | 124.2 kb | Distal (>10kb) Multiome | 808 | |
| chr8:23,224,394–23,225,450 | 63.1 kb | Distal (>10kb) Multiome | 678 | |
| chr8:23,246,206–23,247,324 | 41.5 kb | Distal (>10kb) Multiome | 941 | |
| chr8:23,287,908–23,288,715 | 3 bp | At TSS Multiome | 853 | |
| chr8:23,296,053–23,296,427 | 7.9 kb | Proximal (<10kb) | 205 | |
| chr8:23,403,157–23,405,109 | 116.0 kb | Distal (>10kb) Multiome | 425 | |
| chr8:23,451,094–23,451,922 | 163.4 kb | Distal (>10kb) Multiome | 182 | |
| chr8:23,457,148–23,458,219 | 169.5 kb | Distal (>10kb) Multiome | 736 | |
| chr8:23,486,400–23,487,438 | 198.7 kb | Distal (>10kb) Multiome | 134 | |
| chr8:23,528,169–23,530,101 | 240.7 kb | Distal (>10kb) Multiome | 832 |
Genomic view of the R3HCC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.