This gene encodes a subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine, and tyrosine. The encoded protein may play a role in the queuosine 5'-monophosphate salvage pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for QTRT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = QTRT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of QTRT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:113,838,330–113,839,358 | 217.9 kb | Distal (>10kb) Multiome | 588 | |
| chr3:113,947,254–113,948,963 | 108.9 kb | Distal (>10kb) Multiome | 685 | |
| chr3:114,056,072–114,057,305 | 149 bp | At TSS Multiome | 831 | |
| chr3:114,152,492–114,153,196 | 96.0 kb | Distal (>10kb) Multiome | 653 | |
| chr3:114,153,953–114,154,968 | 97.8 kb | Distal (>10kb) Multiome | 184 | |
| chr3:114,213,304–114,215,564 | 158.0 kb | Distal (>10kb) Multiome | 461 |
Genomic view of the QTRT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.