This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for QTRT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = QTRT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of QTRT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:10,403,282–10,404,914 | 297.8 kb | Distal (>10kb) Multiome | 794 | |
| chr19:10,416,245–10,417,312 | 284.7 kb | Distal (>10kb) Multiome | 988 | |
| chr19:10,417,499–10,421,409 | 281.2 kb | Distal (>10kb) Multiome | 801 | |
| chr19:10,424,198–10,424,839 | 276.9 kb | Distal (>10kb) Multiome | 563 | |
| chr19:10,431,990–10,432,435 | 269.2 kb | Distal (>10kb) Multiome | 301 | |
| chr19:10,460,915–10,461,960 | 240.1 kb | Distal (>10kb) Multiome | 340 | |
| chr19:10,502,251–10,503,615 | 198.6 kb | Distal (>10kb) Multiome HiCAR | 1013 | |
| chr19:10,514,009–10,514,960 | 187.1 kb | Distal (>10kb) Multiome HiCAR | 172 | |
| chr19:10,517,347–10,518,104 | 183.7 kb | Distal (>10kb) Multiome HiCAR | 338 | |
| chr19:10,543,499–10,544,302 | 157.6 kb | Distal (>10kb) Multiome | 617 | |
| chr19:10,565,054–10,566,439 | 135.4 kb | Distal (>10kb) Multiome | 923 | |
| chr19:10,568,225–10,569,839 | 132.4 kb | Distal (>10kb) Multiome | 871 | |
| chr19:10,602,117–10,602,945 | 99.0 kb | Distal (>10kb) Multiome | 518 | |
| chr19:10,625,339–10,625,984 | 75.9 kb | Distal (>10kb) Multiome | 451 | |
| chr19:10,653,364–10,655,129 | 47.3 kb | Distal (>10kb) Multiome | 1086 | |
| chr19:10,695,264–10,696,403 | 5.6 kb | Proximal (<10kb) Multiome | 831 | |
| chr19:10,701,273–10,702,291 | 7 bp | At TSS Multiome | 889 | |
| chr19:10,717,121–10,718,717 | 16.3 kb | Distal (>10kb) Multiome | 849 | |
| chr19:10,835,171–10,836,835 | 134.5 kb | Distal (>10kb) Multiome | 1096 | |
| chr19:10,870,403–10,872,620 | 169.7 kb | Distal (>10kb) Multiome | 714 | |
| chr19:10,928,331–10,929,395 | 227.3 kb | Distal (>10kb) Multiome | 860 | |
| chr19:10,960,232–10,961,863 | 259.4 kb | Distal (>10kb) Multiome | 1016 |
Genomic view of the QTRT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.