QSOX2 is a member of the sulfhydryl oxidase/quiescin-6 (Q6) family (QSOX1; MIM 603120) that regulates the sensitization of neuroblastoma cells for IFN-gamma (IFNG; MIM 147570)-induced cell death (Wittke et al., 2003 [PubMed 14633699]).[supplied by OMIM, Jun 2009]
Transcription factors with Perturb-seq knockdown data for QSOX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = QSOX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of QSOX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:135,960,610–135,961,627 | 284.4 kb | Distal (>10kb) Multiome | 697 | |
| chr9:135,992,635–135,993,405 | 252.7 kb | Distal (>10kb) Multiome | 684 | |
| chr9:136,051,068–136,051,829 | 194.3 kb | Distal (>10kb) Multiome | 353 | |
| chr9:136,094,901–136,095,992 | 150.3 kb | Distal (>10kb) Multiome | 445 | |
| chr9:136,109,321–136,110,010 | 136.2 kb | Distal (>10kb) Multiome | 643 | |
| chr9:136,117,952–136,119,826 | 127.0 kb | Distal (>10kb) Multiome | 931 | |
| chr9:136,132,442–136,133,645 | 112.6 kb | Distal (>10kb) Multiome | 343 | |
| chr9:136,245,219–136,246,310 | 41 bp | At TSS Multiome | 608 | |
| chr9:136,267,002–136,267,928 | 21.6 kb | Distal (>10kb) Multiome | 459 | |
| chr9:136,327,140–136,327,919 | 81.8 kb | Distal (>10kb) Multiome | 310 | |
| chr9:136,342,464–136,343,245 | 97.1 kb | Distal (>10kb) Multiome | 326 | |
| chr9:136,362,899–136,364,677 | 117.5 kb | Distal (>10kb) Multiome | 969 | |
| chr9:136,399,639–136,400,642 | 154.4 kb | Distal (>10kb) Multiome | 776 | |
| chr9:136,410,307–136,410,943 | 164.8 kb | Distal (>10kb) Multiome | 740 | |
| chr9:136,438,826–136,440,227 | 194.0 kb | Distal (>10kb) Multiome | 608 | |
| chr9:136,482,405–136,485,297 | 237.5 kb | Distal (>10kb) Multiome | 938 | |
| chr9:136,545,392–136,547,129 | 300.3 kb | Distal (>10kb) Multiome | 710 |
Genomic view of the QSOX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.