This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for PXN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PXN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PXN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:119,988,471–119,990,364 | 275.7 kb | Distal (>10kb) Multiome | 892 | |
| chr12:120,086,807–120,087,619 | 178.6 kb | Distal (>10kb) Multiome | 957 | |
| chr12:120,093,667–120,094,287 | 171.7 kb | Distal (>10kb) Multiome HiCAR | 172 | |
| chr12:120,116,125–120,117,765 | 148.9 kb | Distal (>10kb) Multiome | 903 | |
| chr12:120,194,328–120,196,208 | 71.0 kb | Distal (>10kb) Multiome HiCAR | 1032 | |
| chr12:120,200,671–120,201,921 | 64.5 kb | Distal (>10kb) Multiome HiCAR | 1006 | |
| chr12:120,228,170–120,231,900 | 37.2 kb | Distal (>10kb) Multiome HiCAR | 1050 | |
| chr12:120,265,150–120,266,362 | 36 bp | At TSS Multiome | 617 | |
| chr12:120,290,301–120,293,526 | 27.4 kb | Distal (>10kb) Multiome | 1338 | |
| chr12:120,302,138–120,302,609 | 36.5 kb | Distal (>10kb) Multiome | 711 | |
| chr12:120,317,215–120,317,997 | 51.9 kb | Distal (>10kb) Multiome | 872 | |
| chr12:120,361,277–120,362,299 | 96.0 kb | Distal (>10kb) Multiome | 308 | |
| chr12:120,368,637–120,370,303 | 103.4 kb | Distal (>10kb) Multiome | 250 | |
| chr12:120,388,762–120,389,560 | 123.4 kb | Distal (>10kb) Multiome | 178 | |
| chr12:120,394,470–120,395,052 | 129.0 kb | Distal (>10kb) Multiome | 283 | |
| chr12:120,413,842–120,414,516 | 148.4 kb | Distal (>10kb) Multiome | 289 | |
| chr12:120,437,436–120,438,568 | 172.2 kb | Distal (>10kb) Multiome | 725 | |
| chr12:120,445,927–120,446,970 | 180.7 kb | Distal (>10kb) Multiome | 982 | |
| chr12:120,468,864–120,470,390 | 204.0 kb | Distal (>10kb) Multiome | 942 | |
| chr12:120,495,362–120,496,939 | 230.2 kb | Distal (>10kb) Multiome | 794 | |
| chr12:120,528,856–120,529,468 | 263.4 kb | Distal (>10kb) Multiome | 849 | |
| chr12:120,534,230–120,535,077 | 268.7 kb | Distal (>10kb) Multiome | 730 |
Genomic view of the PXN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.