Predicted to enable heme binding activity and peroxidase activity. Predicted to be involved in hydrogen peroxide catabolic process. Predicted to be located in endoplasmic reticulum; extracellular region; and plasma membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PXDNL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PXDNL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PXDNL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:51,553,857–51,554,935 | 255.1 kb | Distal (>10kb) Multiome | 76 | |
| chr8:51,809,065–51,809,854 | at TSS | At TSS | 153 | |
| chr8:51,898,289–51,900,140 | 89.7 kb | Distal (>10kb) Multiome | 870 | |
| chr8:51,945,159–51,946,047 | 136.4 kb | Distal (>10kb) Multiome | 70 | |
| chr8:51,973,177–51,974,076 | 164.2 kb | Distal (>10kb) Multiome | 350 | |
| chr8:52,008,125–52,008,999 | 199.2 kb | Distal (>10kb) Multiome | 473 | |
| chr8:52,100,809–52,101,366 | 291.6 kb | Distal (>10kb) Multiome | 219 |
Genomic view of the PXDNL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.