Enables NuRD complex binding activity; chromatin binding activity; and methylated histone binding activity. Involved in chromatin remodeling. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PWWP2A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PWWP2A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PWWP2A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:159,915,806–159,917,141 | 203.0 kb | Distal (>10kb) Multiome | 380 | |
| chr5:159,971,757–159,973,420 | 147.2 kb | Distal (>10kb) Multiome | 189 | |
| chr5:159,986,837–159,987,682 | 132.0 kb | Distal (>10kb) Multiome | 416 | |
| chr5:160,008,719–160,009,383 | 110.3 kb | Distal (>10kb) Multiome | 737 | |
| chr5:160,118,295–160,120,363 | 234 bp | At TSS Multiome | 890 | |
| chr5:160,133,074–160,134,351 | 14.2 kb | Distal (>10kb) Multiome | 270 | |
| chr5:160,159,956–160,160,873 | 40.8 kb | Distal (>10kb) Multiome | 276 | |
| chr5:160,161,037–160,162,516 | 42.5 kb | Distal (>10kb) Multiome | 167 | |
| chr5:160,165,122–160,166,166 | 46.4 kb | Distal (>10kb) Multiome | 537 | |
| chr5:160,188,095–160,189,161 | 69.2 kb | Distal (>10kb) Multiome | 472 | |
| chr5:160,199,034–160,200,016 | 80.2 kb | Distal (>10kb) Multiome | 455 | |
| chr5:160,287,012–160,288,061 | 168.2 kb | Distal (>10kb) Multiome | 461 | |
| chr5:160,311,564–160,313,046 | 193.2 kb | Distal (>10kb) Multiome | 576 | |
| chr5:160,344,991–160,345,682 | 226.0 kb | Distal (>10kb) Multiome | 420 | |
| chr5:160,399,366–160,400,211 | 280.4 kb | Distal (>10kb) Multiome | 808 | |
| chr5:160,418,768–160,419,557 | 299.7 kb | Distal (>10kb) Multiome | 703 |
Genomic view of the PWWP2A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.