The exact function of this gene is not known, however, its encoded product is highly similar to purine-rich element binding protein A. The latter is a DNA-binding protein which binds preferentially to the single strand of the purine-rich element termed PUR, and has been implicated in the control of both DNA replication and transcription. This gene lies in close proximity to the Werner syndrome gene, but on the opposite strand, on chromosome 8p11. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for PURG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PURG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PURG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:30,743,665–30,744,537 | 289.5 kb | Distal (>10kb) Multiome | 789 | |
| chr8:30,811,955–30,813,256 | 220.9 kb | Distal (>10kb) Multiome | 824 | |
| chr8:30,817,124–30,817,779 | 216.3 kb | Distal (>10kb) Multiome | 166 | |
| chr8:30,911,618–30,912,683 | 121.5 kb | Distal (>10kb) Multiome | 460 | |
| chr8:31,032,234–31,034,302 | 23 bp | At TSS Multiome | 723 | |
| chr8:31,034,565–31,034,905 | 850 bp | At TSS | 263 | |
| chr8:31,238,723–31,239,626 | 205.4 kb | Distal (>10kb) Multiome | 327 |
Genomic view of the PURG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.