This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Transcription factors with Perturb-seq knockdown data for PTTG1IP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTTG1IP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTTG1IP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:44,686,253–44,687,168 | 187.0 kb | Distal (>10kb) Multiome | 199 | |
| chr21:44,711,499–44,711,908 | 161.9 kb | Distal (>10kb) Multiome | 168 | |
| chr21:44,748,550–44,748,985 | 124.8 kb | Distal (>10kb) Multiome | 149 | |
| chr21:44,801,527–44,802,290 | 71.8 kb | Distal (>10kb) Multiome | 818 | |
| chr21:44,817,098–44,818,998 | 55.8 kb | Distal (>10kb) Multiome | 775 | |
| chr21:44,845,753–44,846,245 | 27.7 kb | Distal (>10kb) Multiome | 504 | |
| chr21:44,872,991–44,875,251 | 81 bp | At TSS Multiome | 841 | |
| chr21:44,939,797–44,940,292 | 66.3 kb | Distal (>10kb) Multiome | 1041 | |
| chr21:45,073,773–45,075,747 | 200.8 kb | Distal (>10kb) Multiome | 883 |
Genomic view of the PTTG1IP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.