The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PTPRA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPRA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPRA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:2,651,802–2,653,286 | 220.9 kb | Distal (>10kb) Multiome | 1060 | |
| chr20:2,663,925–2,664,409 | 209.2 kb | Distal (>10kb) Multiome | 908 | |
| chr20:2,692,159–2,694,013 | 180.8 kb | Distal (>10kb) Multiome | 584 | |
| chr20:2,752,636–2,753,047 | 120.7 kb | Distal (>10kb) Multiome | 395 | |
| chr20:2,800,326–2,801,021 | 72.7 kb | Distal (>10kb) Multiome | 349 | |
| chr20:2,840,006–2,841,330 | 32.8 kb | Distal (>10kb) Multiome | 997 | |
| chr20:2,872,329–2,874,047 | 112 bp | At TSS Multiome | 980 | |
| chr20:3,045,415–3,046,996 | 172.5 kb | Distal (>10kb) Multiome | 999 | |
| chr20:3,071,569–3,072,466 | 198.8 kb | Distal (>10kb) Multiome | 214 | |
| chr20:3,092,619–3,093,442 | 219.6 kb | Distal (>10kb) Multiome | 180 | |
| chr20:3,159,566–3,160,153 | 286.5 kb | Distal (>10kb) Multiome | 1027 | |
| chr20:3,168,012–3,168,864 | 295.0 kb | Distal (>10kb) Multiome | 598 | |
| chr20:3,172,885–3,174,573 | 300.2 kb | Distal (>10kb) Multiome | 1012 |
Genomic view of the PTPRA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.