Enables phosphotyrosine residue binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in membrane and nucleoplasm. Predicted to be active in cell junction; cytosol; and plasma membrane. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PTPN5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PTPN5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PTPN5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:18,526,292–18,527,325 | 265.0 kb | Distal (>10kb) Multiome | 1012 | |
| chr11:18,588,293–18,589,047 | 203.1 kb | Distal (>10kb) Multiome | 837 | |
| chr11:18,633,863–18,635,078 | 157.3 kb | Distal (>10kb) Multiome | 834 | |
| chr11:18,698,354–18,699,356 | 93.0 kb | Distal (>10kb) Multiome | 586 | |
| chr11:18,720,706–18,722,495 | 69.5 kb | Distal (>10kb) Multiome | 447 | |
| chr11:18,790,876–18,792,822 | 134 bp | At TSS Multiome | 294 |
Genomic view of the PTPN5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.